All About AMPK Activators
To ensure that the body is functioning properly, AMPK is crucial as it is regulating the maintenance of cellular energy homeostasis. Now in mammals, AMPK is regulating the energy balance at both on cellular level by means of sensing ATP/AMP and ATP/ADP ratio levels and whole body level through response to the hormones and the brain.
ATP is actually the most significant energy molecule present in the body. To make it simpler, this is the point where cellular function starts. ATP breaks down into ADP that has less potential for energy since the cells are using energy. Then after, ADP breaks down to AMP that has got the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.
There are different mechanisms in which AMPK acts on. This makes sense since AMPK is the master regulator of all functioning cells. The effect that AMPK activation in the body depend on the complicated balance of factors and the signaling pathways. Still, there are many different benefits of having increased AMPK and these are:
Anti aging – AMPK activation is gradually declining as we are aging. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. It is promoting cellular renewal and also, the production of new mitochondria.
Anti inflammation – inflammation decreases the level of AMPK activation in the body but what’s interesting is that, AMPK is used as well to decrease inflammation.
Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.
There are lots of herbal products/constituents and nutritional products too that are proven to be effective as AMPK activator and few of these are:
Number 1. AICAR – in AMP, AICAR is considered as its analog that is necessary for cellular use and storage similar to ATP. AICAR has been studied and discovered to directly affect AMPKs activity that helps it to improve muscle performance all because it’s the analog of AMP.
Number 2. ALA – in this case, it’s Alpha Lipoic Acid that is known to be an effective antioxidant but it’s a useful AMPK activator too. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.
Number 3. Green tea extract – actually, this was discovered to assist in the activation of AMPK by activating upstream kinase.
Number 4. Berberine – because of its AMPK activation, berberine was discovered to carry the same anti diabetic effects as metformin.