Role of blood vessels in liver disease

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Professor Anna Randi, Head of Vascular Science at Imperial’s National Heart and Lung Institute, and leader of the research, said: “We have found that the master regulator of endothelial cells, ERG, is not only essential to maintain the health of blood vessels, but also of the tissue around blood vessel, in this case the liver; its loss pre-disposes tissue to becoming fibrotic and dysfunctional.”

Blood vessel 'master gene' discovery could lead to treatments for liver disease

She added: “The study shows how acute and chronic inflammation can dramatically affect the activity of this master gene which is essential for  function, with profound consequences not only for the vasculature but also for the surrounding tissue function, which leads to liver damage. This is an exciting finding, as it opens a new way to prevent or treat liver disease by targeting the endothelium.”

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